Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na /K -ATPases. Na /K -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na /K -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.
References
External links
- Human ATP1A1 genome location and ATP1A1 gene details page in the UCSC Genome Browser.
- Human ATP1A4 genome location and ATP1A4 gene details page in the UCSC Genome Browser.
Further reading
